Table 2.

Effect of Sildenafil on Systolic (Sys) and Diastolic (Dia) Blood Pressure (P; mm Hg) of Human Volunteers

Subject Age	Sex	Baseline Pressure				Pressure after Oral Sildenafil (100 mg) Administered at 9:15 am								Change in Systolic Pressure from Baseline
		8:45 am		9:15 am		10:15 am		10:45 am		11:15 am		12:00 pm		At 60 min	At 90 min
		Sys P	Dia P	Sys P	Dia P	Sys P	Dia P	Sys P	Dia P	Sys P	Dia P	Sys P	Dia P
30	F	110	70	110	70	90	50	85	50	110	70	100	60	−20	−25
24	F	100	70	100	60	95	60	90	60	90	60	90	60	−5	−10
74	M	135	90	140	80	110	70	100	60	120	75	130	80	−30	−40
44	F	110	70	110	70	110	60	85	55	110	70	100	60	0	−25
32	M	125	80	120	80	100	70	120	80	120	80	120	80	−20	0
35	M	130	80	130	90	110	80	110	80	120	80	130	80	−20	−20
18	M	110	75	110	70	100	70	90	60	100	70	110	70	−10	−20
40	M	130	80	130	80	125	80	120	80	125	80	120	80	−5	−10
20	M	115	75	110	75	100	60	100	60	100	60	95	60	−10	−10
Mean:				117.8	75.0	104.4*	66.7*	100.0*	65.0*	110.5*	71.7**	110.6*	70.0*	−13.4	−17.8
SEM:				4.3	2.9	3.5	3.3	4.6	3.9	3.9	2.6	5.0	3.3	3.2	3.9
n:				9	9	9	9	9	9	9	9	9	9	9	9

^*Significantly less than its respective 9:15 am baseline value (P< 0.05) as paired, one-tailed data.

^**Marginally less than its respective 9:15 am baseline value (P< 0.06) as paired, one-tailed data.