Table 3.
Effect of Placebo on IOP (mm Hg) of Human Volunteers
| Subject Age | Sex | Baseline Pressure | Pressure after Oral Placebo Administered at 9:15 am | Change in IOP from Baseline | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 8:45 am | 9:15 am | 10:15 am | 10:45 am | 11:15 am | 12:00 pm | At 60 min | At 165 min | ||||||||
| OD | OS | OD | OS | OD | OS | OD | OS | OD | OS | OD | OS | ||||
| 30 | F | 13 | 13.5 | 12.5 | 14 | 13 | 14 | 12 | 13 | 12.5 | 12 | 12 | 13 | 0.3 | −0.8 |
| 24 | F | 16 | 16 | 15 | 16 | 15.5 | 16 | 15 | 16 | 15 | 14 | 16 | 15 | 0.3 | 0 |
| 74 | M | 10 | 11 | 10.5 | 10 | 11 | 10.5 | 10 | 11 | 11 | 10 | 11.5 | 10 | 0.5 | 0.5 |
| 44 | F | 16 | 15 | 16 | 15.5 | 15 | 15.5 | 15 | 16 | 15 | 15 | 16 | 15.5 | −0.5 | 0 |
| 32 | M | 11 | 12 | 13 | 12 | 12 | 13 | 14 | 13 | 14 | 12.5 | 0 | 0.8 | ||
| 35 | M | 11 | 11 | 11.5 | 12.5 | 12 | 12 | 13 | 12 | 12.5 | 12 | 0 | 0.3 | ||
| 18 | M | 13 | 12 | 12 | 12 | 13 | 13 | 10 | 12 | 11 | 12.5 | 1 | −0.3 | ||
| 40 | M | 13 | 13 | 12 | 13 | 13 | 13 | 12 | 13 | 13 | 13 | 0.5 | 0.5 | ||
| 20 | M | 12 | 12 | 12.5 | 13 | 14 | 14 | 12 | 11 | 12 | 12.5 | 1.5 | −0.5 | ||
|
| |||||||||||||||
| Mean: | 12.9 | 13.3 | 13.0 | 0.4 | 0.1 | ||||||||||
| SEM: | 0.6 | 0.5 | 0.6 | 0.2 | 0.2 | ||||||||||
| n: | 9 | 9 | 9 | 9 | 9 | ||||||||||
Mean IOP was calculated from the average of the OD and OS values of each individual.