Table 4.

Methadone (MTD) and 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) concentrations and EDDP/MTD ratios in 19 umbilical cord and matched placenta and meconium specimens from pregnant women receiving methadone-assisted pharmacotherapy.

	Umbilical Cord (ng/g)			Placenta (ng/g)			Meconium (ng/g)
Subject	MTD	EDDP	EDDP/MTD	MTD	EDDP	EDDP/MTD	MTD	EDDP	EDDP/MTD
1	29.7	8.2	0.28	308.0	35.9	0.12	2,555	10,546	4.1
2	130.6	89.5	0.69	1,553.9	147.8	0.10	4,997	28,628	5.7
3	101.1	71.2	0.70	537.3	78.6	0.15	7,281	57,600	7.9
4	53.5	52.8	0.99	549.2	96.1	0.18	5,481	34,753	6.3
5	118.1	74.4	0.63	1,092.4	105.6	0.10	6,373	44,369	7.0
6	193.2	45.4	0.24	2,647.0	517.4	0.20	2,184	53,142	24.3
7	62.2	51.3	0.83	405.2	71.7	0.18	85	6,375	75.0
8	202.6	240.8	1.19	1,538.2	312.3	0.20	11,334	53,800	4.7
9	262.2	42.9	0.16	1,372.1	105.5	0.07	-	-	-
10	151.0	54.5	0.36	1,511.6	120.7	0.08	5,785	32,826	5.7
11	108.6	44.4	0.41	1,048.6	90.4	0.09	5,009	64,800	12.9
12	98.0	40.3	0.41	1,198.6	95.9	0.09	5,235	80,503	15.4
13	87.7	63.3	0.72	1,724.3	213.5	0.12	18,840	62,600	3.3
14	168.0	21.6	0.13	1,784.2	78.4	0.04	2,548	22,900	9.0
15	169.2	58.1	0.34	2,627.0	302.0	0.11	-	-	-
16	185.9	45.9	0.25	1,441.6	86.9	0.06	2,492	13,188	5.3
17	192.1	138.6	0.72	2,643.5	189.0	0.07	21,902	57,200	2.6
18	184.6	54.6	0.30	1,909.0	142.2	0.07	5,047	38,675	7.7
19	167.8	48.4	0.29	1,985.9	103.9	0.05	9,864	33,352	3.4
Mean	140.3	65.6	0.51	1,467.2	152.3	0.11	6,883.1	40,897.5	11.8
SD	59.8	50.2	0.30	720.4	115.4	0.05	5,804.6	20,922.8	17.2
Median	151.0	52.8	0.41	1,511.6	105.5	0.10	5,235.0	38,675.0	6.3

A dash indicates that the testing was not done