Table 3.
CYP19 exon I.6 genotype (rs10459592) and HBV/HCV status in relation to risk of hepatocellular carcinoma (HCC), the Los Angeles County and Guangxi case-control studies
| CYP19 I.6 genotype | Los Angeles | Guangxi | Total | |||
|---|---|---|---|---|---|---|
| CA/COa | OR (95% CI)b | CA/COa | OR (95% CI)b | CA/COa | OR (95% CI)c | |
| HBV and HCV negative | ||||||
| AA | 9/40 | 1.00 | 14/76 | 1.00 | 23/116 | 1.00 |
| AC | 32/86 | 1.75 (0.73–4.19) | 19/97 | 1.14 (0.52–2.52) | 51/183 | 1.37 (0.77–2.44) |
| CC | 22/41 | 2.79 (1.07–7.24) | 11/33 | 2.14 (0.82–5.55) | 33/74 | 2.25 (1.18–4.31) |
| P for trend | 0.032 | 0.150 | 0.014 | |||
| HBV or HCV positive | ||||||
| AA | 10/3 | 1.00 | 78/9 | 1.00 | 88/12 | 1.00 |
| AC | 50/18 | 1.20 (0.21–6.74) | 91/18 | 0.50 (0.21–1.21) | 141/36 | 0.61 (0.29–1.30) |
| CC | 12/5 | 1.17 (0.15–9.28) | 31/9 | 0.33 (0.11–0.94) | 43/14 | 0.48 (0.20–1.19) |
| P for trend | 0.905 | 0.032 | 0.107 | |||
a
CA/CO, number of cases/number of controls.
b
Adjusted for age, sex, race/ethnicity, level of education, number of cigarettes smoked per day and number of alcoholic drinks per day.
c
Additionally adjusted for study location