. Author manuscript; available in PMC: 2012 Aug 15.

Published in final edited form as: Biochem Pharmacol. 2011 May 18;82(4):411–417. doi: 10.1016/j.bcp.2011.05.009

Table 3.

Profile of deoxyribonucleotide pool normalized with ATP.

Compound	Retention time(min)	ionization mode	linear range(pmol)	PANC1	1975	HepG2	H23

				pmol/10⁶cell
dATP	39.5	negative	0.25 - 60	28.50±1.56	16.57 ± 0.89	4.24 ± 0.34	12.75 ± 0.84
dADP	23.1	negative	0.072 - 5.6	0.65±0.07	0.28 ± 0.04	0.00 ± 0.00	0.00 ± 0.00
dAMP	16.6	negative	0.0086 - 1.36	0.08±0.01	0.03 ± 0.00	0.08 ± 0.02	0.00 ± 0.00
dGTP	41.0	positive	0.25 - 60	15.77±0.72	7.60 ± 0.40	7.40 ± 0.72	7.07 ± 0.56
dGDP	23.6	positive	0.082-10.4	2.69±0.19	1.06 ± 0.07	1.37 ± 0.20	0.96 ± 0.25
dGMP	15.3	positive	0.1 - 12.8	UDL^*	UDL^*	UDL^*	UDL^*
dCTP	30.8	negative	0.25 - 60	18.54±1.00	7.96 ± 0.67	4.20 ± 0.40	9.12 ± 0.66
dCDP	20.2	negative	0.076-6.166	UDL^*	UDL^*	UDL^*	UDL^*
dCMP	10.6	negative	0.1 - 8	1.40±0.20	0.29 ± 0.04	1.45 ± 0.18	0.82 ± 0.05
dUTP	42.4	negative	0.95 - 38	UDL^*	UDL^*	UDL^*	UDL^*
dUDP	21.7	negative	0.1-16	UDL^*	UDL^*	UDL^*	UDL^*
dUMP	13.5	negative	0.1 - 8	6.36±1.12	8.15 ± 1.52	23.77 ± 4.79	3.55 ± 0.95
TTP	41.2	negative	0.25 - 60	91.64±4.26	62.12 ± 2.54	18.35 ± 1.63	68.32 ± 7.33
TDP	22.8	negative	0.42 - 9	20.23±2.28	13.74 ± 1.52	13.80 ± 1.80	11.72 ± 1.31
TMP	14.8	negative	0.0172 - 1.36	0.42±0.07	0.14±0.02	0.95 ± 0.18	0.17 ± 0.03

Note: Each data point is an average of two independent experiments (done in triplicate) and is reported as mean ± standard deviation.

UDL, under detected limit of assay.