Figure 3.
Localization of in vivo luciferase expression after a single intra-articular injection of AAV-CMV-Luc by using the IVIS optical imaging system. (A) Luciferase was detected in the intact left knee joint. (B) Exposure of the intra-articular space of the same knee joint in (A) revealed that the luciferase signal was located in 2 major areas. (C) A higher magnification of (B) indicated that the signal was mainly found in the infrapatellar fat pad and in the soft tissues between the femur and tibia, such as the ligaments and meniscus.