. Author manuscript; available in PMC: 2012 Feb 1.

Published in final edited form as: Cancer Gene Ther. 2011 Mar 11;18(8):533–542. doi: 10.1038/cgt.2011.6

Table 3.

Bystander in vivo growth of rat C6 tumors containing an 80:20 ratio of vector transfected (pcDNA) to transfected (yCD_double, yCD_double/yUPRT, bCD₁₅₂₅, or bCD₁₅₂₅/bUPRT) cells in response to PBS or 5FC treatment.

	Mean tumor volume (mm³)

	Day 0	Day 16

	5FC (375mg kg^-1)	PBS	5FC (375mg kg^-1)
yCD_double	10.42 (0.96)^a	1010.8 (128.84)	718.88 (82.2)^**
yCD_double/yUPRT	6.78 (0.76)	705.98 (170.6)	810.62 (142.01)^**
bCD₁₅₂₅	8.88 (1.19)	1066.5 (196.17)	179.57 (28.9)
bCD₁₅₂₅/bUPRT	8.23 (0.65)	638.0 (70.33)	432.51 (53.68)^**

Standard error mean.

^**

P≤0.005 (bCD₁₅₂₅ vs. bCD_152S/bUPRT tumor volume) or 0.0005 (bCD₁₅₂₅ vs. yCD_double and yCD_double/yUPRT tumor volumes) (n = 5).

5FC, 5-fluorocytosine; bCD or yCD, bacterial or yeast cytosine deaminase; bUPRT or yUPRT, bacterial or yeast uracil phosphoribosyltransferase; PBS, phosphate buffered saline.