Table 4.

Results of vaginal cultures for six weeks after the vaginal challenge

Antigen	Immunization route/(times)	Percentage of mice with positive vaginal cultures and median number of C. trachomatis IFUa (range)										Total # mice that shed over 6 wks (% positive)
		Week 1		Week 2		Week 3		Week 4		Weeks 5/6
		Mice	IFU	Mice	IFU	Mice	IFU	Mice	IFU	Mice	IFU
rMOMP	i.vag./col. (4X)	79	440,586 (<2-2,529,340)	57	9,717 (<2-550,434)	29	<2 (<2-33,522)	0	<2	0	<2	11/14 (79)
rMOMP	i.n./s.l. (4X)	60	74,292 (<2-1,372,624)	53	6 (<2-420,288)	20	<2 (<2-60,894)	7	<2 (<2-2,478)	0	<2	10/15 (67)
rMOMP	i.m./s.c. (4X)	38b	<2 (<2-790,550)c	38	<2 (<2-126,564)	19	<2 (<2-1,809)	5	<2 (<2-16)	0	<2	9/21b (43)
rMOMP	i.vag./col. (2X) + i.m./s.c. (2X)	29 b,d,e	<2 (<2-1,610,848)c	19 b,d	<2 (<2-114,624)c,f,g	10	<2 (<2-595)f	5	<2 (<2-451)	0	<2	6/21b,d,e (29)
rMOMP	i.n./s.l. (2X) + i.m./s.c. (2X)	19 b,d,e	<2 (<2-2,963,620)c,f,g	19 b,d	<2 (<2-365,844)c,f,g	19	<2 (<2-287,854)	0	<2	0	<2	5/21b,d,e (24)
MoPn	i.n. (1X)	0 b,d,e	<2 c,f,g	0 b,d,e	<2 c,f,g	0 b,d	<2 c,f,g	0	<2	0	<2	0/15b,d,e (0)
Ng-rPorB	i.m./s.c. (4X)	69	10,219 (<2-771,324)	63	5,186 (<2-767,742)	38	70 (<2-66,864)	13	<2 (<2-392)	0	<2	11/16 (69)

^aLimit of detection: 2 IFU.

^bP<0.05 by the Fisher’s Exact test compared to the i.vag./col. (4X) immunization group

^cP<0.05 by the Mann Whitney U test compared to the i.vag./col. (4X) immunization group.

^dP<0.05 by the Fisher’s Exact test compared to the Ng-rPorB immunization group.

^eP<0.05 by the Fisher’s Exact test compared to the i.n./s.l. (4X) immunization group.

^fP<0.05 by the Mann Whitney U test compared to the Ng-rPorB immunization group.

^gP<0.05 by the Mann Whitney U test compared to the i.n./s.l. (4X) immunization group.