Table 4.
Association of T cell activation and senescence with measures of carotid artery stiffness among HIV-infected women, after adjustment for total CD4+ T cell count and HIV RNA
Change in distensibility per unit change in predictor | 95% confidence interval | P | Change in Young’s modulus per unit change in predictor | 95% confidence interval | P | |
---|---|---|---|---|---|---|
CD4+CD38+HLA-DR+ T cells | −2.12 | −4.14, −0.11 | 0.04 | 1.00 | −0.06, 2.05 | 0.06 |
CD8+CD38+HLA-DR+ T cells | −1.73 | −3.96, 0.49 | 0.13 | 0.80 | −0.36, 1.96 | 0.18 |
CD4+CD28-CD57+ T cells | −0.78 | −1.57, 0 | 0.05 | 0.32 | −0.09, 0.73 | 0.13 |
CD8+CD28-CD57+ T cells | −2.61 | −5.15, −0.07 | 0.04 | 0.88 | −0.46, 2.21 | 0.19 |
CD4+ T cell count (per 100 cells/mL) | 0.01 | −0.04, 0.06 | 0.78 | 0.01 | −0.02, 0.03 | 0.73 |
HIV RNA (per log10 copies/mL) | −0.65 | −1.94, 0.65 | 0.32 | 0.40 | −0.28, 1.07 | 0.24 |
Adjusted for age, body mass index, smoking, use of antiretroviral medications, CD4+ count, HIV RNA, and T cell activation or senescence