Table 4.

Toxicities in trials comparing rituximab maintenance vs observation in follicular lymphoma

Reference	No of. patients	Grade 3-4 AE	Neutropenia (grade 3-4)	Grade 3-4 Infections
Haisworth et al[16]	62	9% vs 4%	2% vs 0%	0
Ghielmini et al[14] Martinelli et al[19]	185	28% vs 20%	18% vs 17%	NA
Hochster et al[17]	228	NA	3% vs 1%	1% vs 1%
Forstpointner et al[10]	105	NA	13% vs 6%	4% vs 3%
van Oers et al[6]	334	NA	10.8% vs 5.4%(P = 0.07)	9% vs 2.4% (P = 0.009)
Salles et al[18,23]	1018	23% vs 16%	4% vs 1%	4% vs 1%