Table 3.
The effects of the Mn exposure (200 and 800 μM) and/or SIL 50 μM on intracellular GSH concentration, thiol (SH) and disulfide (SS) contents, and SH/SS ratio measured in Neuro-2A cells homogenates
| Groups | ||||||
|---|---|---|---|---|---|---|
| Control | SIL50 | Mn200 | Mn800 | M 200 + SIL50 | Mn800 + SIL50 | |
| GSH | 46.44 ± 4.26 | 45.07 ± 2.13 | 30.53 ± 3.34*** | 22.26 ± 4.37*** | 34.92 ± 3.50### | 33.64 ± 3.93# |
| SH content | 25.38 ± 3.25 | 25.05 ± 3.17 | 19.90 ± 0.15*** | 16.5 ± 0.49*** | 22.40 ± 0.70# | 20.51 ± 0.35### |
| SS content | 5.43 ± 0.36 | 5.91 ± 0.35 | 10.45 ± 0.17*** | 14.90 ± 1.25*** | 8.25 ± 0.93## | 10.45 ± 0.65### |
| SH/SS ratio | 4.96 ± 0. 29 | 5.05 ± 0.25 | 2.00 ± 0.18*** | 1.25 ± 0.40*** | 2.48 ± 0.13# | 2.25 ± 0.11### |
Data are expressed as GSH (μmol/106cells), SH and SS (nmol TNB/mg protein)
Results represent mean ± SD (n = 6)
* P < 0.05; ** P < 0.01,; *** P < 0.001 versus vehicle control group
# P < 0.05, ## P < 0.01, ### P < 0.001 versus Mn-treated alone group