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. Author manuscript; available in PMC: 2012 Jul 22.
Published in final edited form as: J Mol Biol. 2011 Jul 22;410(4):716–725. doi: 10.1016/j.jmb.2011.04.069

FIGURE 7. A model linking Spry2 control of Ca2+ release from IP3R-gated stores to IP3R control of Spry2 at the plasma membrane.

FIGURE 7

The blockade to release of Ca2+ from the IP3R-gated stores due to the Spry2-mediated inhibition of PI(4,5)P2 hydrolysis (red lines and font) may signal disruption of Spry2-PI(4,5)P2 binding at the plasma membrane (green line).