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Upper panel: plot showing significant differences in ventral striatum/ventral pallidum (VS/VP) region of interest [11C]P943 binding potential (BPND) between patients with major depressive disorder (MDD) and healthy control subjects (HC). Lower panel: average [11C]P943 BPND co-registered positron emission tomography images illustrate reduced VS/VP [11C]P943 BPND in MDD (right) relative to HC (left)
