Figure 2.

Effects of juvenile exposure to VEH, MPH, FLX, or MPH + FLX on cocaine-induced place conditioning. A, Short term (24 h after the last injection): MPH blunted, whereas FLX increased preference for environments previously paired with cocaine (10 mg/kg). MPH + FLX increased preference for the cocaine-paired compartment at 5 and 10 mg/kg doses when compared with the VEH-pretreated controls (n = 5–9 per group; p < 0.05, respectively). B, Long term (2 months after the last injection): MPH-pretreated rats showed a significant aversion to the cocaine-paired compartments, regardless of dose, whereas FLX and MPH + FLX pretreatment increased preference for the cocaine-paired compartments (5 and 10 mg/kg) when compared with VEH-pretreated controls (n = 5–8 per group; p < 0.05, respectively). *Significantly different from the VEH-pretreated controls at same dose, p < 0.05. ^βSignificantly different (p < 0.05) from rats conditioned to saline (i.e., 0 mg/kg cocaine dose). ^ωSignificantly different from the FLX-pretreated rats at same dose (p < 0.05). Data are presented as time spent in the cocaine-paired compartment (drug minus saline side) on test day (mean ± SEM).