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. 2011 Jul 13;31(28):10347–10358. doi: 10.1523/JNEUROSCI.1470-11.2011

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Copyright © 2011 the authors 0270-6474/11/3110347-12$15.00/0

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Figure 4. — Effects of juvenile exposure to VEH, MPH, FLX, or MPH + FLX on anxiety-like behavior in the elevated plus maze. Short term (24 h after the last injection; n = 7–8 per group): Only MPH-pretreated rats spent significantly (p < 0.05) less time in the open arms when compared with the VEH-pretreated controls (left panel). Long term (2 months after the last injection; n = 8–12 per group): MPH, FLX, and MPH + FLX decreased time spent in the open arms when compared with the VEH-pretreated controls (p < 0.05; right panel). *Significantly different from the VEH-pretreated controls. Data are presented as percentage time (mean ± SEM).