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. 2011 Jul 13;31(28):10347–10358. doi: 10.1523/JNEUROSCI.1470-11.2011

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Copyright © 2011 the authors 0270-6474/11/3110347-12$15.00/0

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Figure 6. — Short-term effects of juvenile exposure to VEH, MPH, FLX, or MPH + FLX on ERK-related gene expression within the VTA 24 h after the last injection (n = 8 per group). A, ERK2 mRNA was decreased after MPH and FLX treatment (p < 0.05), but increased after MPH + FLX treatment when compared with VEH-pretreated controls (p < 0.05). B, CREB mRNA was decreased after exposure to MPH and FLX (p < 0.05), but increased after MPH + FLX when compared with the VEH-pretreated controls (p < 0.05). C, D, BDNF (C) and c-Fos (D) mRNA did not vary by treatment. E, Zif268 mRNA was increased after MPH and MPH + FLX (p < 0.05), but did not vary after FLX when compared with the VEH-pretreated controls. F, mTOR mRNA was increased after FLX and MPH (p < 0.05), but did not vary after MPH + FLX exposure when compared with the VEH-pretreated controls. *Significantly different from the VEH-pretreated controls (p < 0.05). Data are presented as fold change normalized to GAPDH (mean ± SEM).