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. 2011 Jul 13;31(28):10347–10358. doi: 10.1523/JNEUROSCI.1470-11.2011

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Copyright © 2011 the authors 0270-6474/11/3110347-12$15.00/0

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Figure 7. — Long-term effects of juvenile exposure to VEH, MPH, FLX, or MPH + FLX on ERK-related gene expression within the VTA 2 months after the last injection (n = 8 per group). A, B, ERK2 (A), CREB (B) mRNA increased after MPH + FLX (p < 0.05), but not after MPH or FLX (p > 0.05) when compared with the VEH-pretreated rats. C, BDNF mRNA did not vary after MPH (p > 0.05), but was decreased following FLX, and increased after MPH + FLX exposure (p < 0.05, respectively) when compared with the VEH-pretreated controls. D, c-Fos mRNA was increased after MPH and MPH + FLX (p < 0.05), but did not vary after FLX treatment (p > 0.05) when compared with the VEH-pretreated controls. E, Zif268 mRNA was increased following MPH and MPH + FLX (p < 0.05), but not FLX (p > 0.05) when compared with the VEH-pretreated controls. F, mTOR mRNA was decreased by MPH and increased by MPH + FLX (p < 0.05), but did not vary after FLX exposure (p > 0.05) when compared with the VEH-pretreated controls. *Significantly different from VEH-pretreated controls (p < 0.05). Data are presented as fold change normalized to GAPDH (mean ± SEM).