Figure 5.

Relationship between cross-frequency modulation and patient symptoms. (A) Plot of correlation coefficients between IC_M loading parameters (averaged over condition) and positive (red), negative (blue), and general (black) symptom scores. Only patients with PANSS scores collected within 2 weeks EEG acquisition were included in this analysis (n = 25). Error bars ( ± 1 SEM) estimated with 1000 bootstrap resamplings. A single significant correlation (indicated by the asterisk, after Bonferroni correction for 18 tests) was found between negative symptoms and IC_M 6 (r = −0.69, P < 0.005). (B) Scatter plot of negative symptom scores and the loading parameters of IC_M 6. Dashed black line represents the least-squares linear fit.