Table 4. Twelve-month comorbidity (odds-ratios) of DSM-IV/CIDI MDE with other 12-month DSM-IV/CIDI disorders by age1.
| Age Groups | Age Difference3 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| All Ages | 18-34 | 35-49 | 50-64 | 65+ | % | OR | |||||||
| %2(se) | OR2(CI) | %2(se) | OR2(CI) | %2(se) | OR2(CI) | %2(se) | OR2(CI) | %2(se) | OR2(CI) | χ23 | |||
| I. Developed | |||||||||||||
| Any other mood disorder4 | 29.8 (1.0) | 43.7*(36.8-51.8) | 24.7 (1.6) | 20.8*(15.8-27.3) | 31.6 (1.8) | 43.9*(32.6-59.0) | 36.7 (2.1) | 96.0*(67.4-136.8) | 30.1 (3.1) | 93.8*(57.4-153.3) | 22.0* | 59.4* | |
| Any anxiety disorder4 | 49.7 (1.2) | 9.3*(8.4-10.3) | 47.7 (1.8) | 6.9*(5.8-8.2) | 54.0 (1.8) | 8.9*(7.4-10.6) | 49.7 (2.4) | 10.1*(8.1-12.7) | 43.5 (3.7) | 15.9*(11.1-22.8) | 5.6 | 11.5* | |
| Any substance disorder4 | 8.6 (0.8) | 4.2*(3.5-5.1) | 14.6 (1.5) | 3.7*(2.8-4.8) | 6.8 (1.0) | 3.6*(2.6-5.0) | 2.0 (0.6) | 3.1*(1.6-5.9) | 0.2 (0.2) | 9.2(0.7-129.0) | 29.6* | 2.1 | |
| Any DSM-IV/CIDI disorder4 | 62.0 (1.2) | 12.6*(11.3-14.1) | 60.2 (1.9) | 8.2*(6.8-9.9) | 66.1 (1.9) | 12.9*(10.7-15.7) | 61.1 (2.3) | 15.0*(11.9-18.8) | 57.1 (3.7) | 25.9*(18.3-36.7) | 3.4 | 28.4* | |
| Number of comorbid DSM-IV/CIDI disorders | |||||||||||||
| One5 | 27.7 (1.1) | 7.8*(6.8-8.9) | 27.1 (1.7) | 5.4*(4.3-6.7) | 28.7 (1.8) | 8.0*(6.4-10.1) | 24.1 (2.2) | 7.5*(5.6-9.9) | 35.0 (3.3) | 18.2*(12.4-26.5) | 3.7 | 23.5* | |
| Two5 | 15.9 (0.8) | 21.2*(18.0-25.1) | 14.2 (1.3) | 11.1*(8.3-14.8) | 17.2 (1.4) | 20.7*(15.5-27.7) | 17.8 (1.9) | 34.7*(24.0-50.2) | 14.5 (2.2) | 80.5*(47.3-136.9) | 5.0 | 43.4* | |
| Three or more5 | 18.7 (0.9) | 55.4*(45.8-67.0) | 19.5 (1.4) | 32.6*(24.5-43.3) | 20.2 (1.5) | 50.5*(36.8-69.2) | 19.4 (2.0) | 86.6*(57.5-130.4) | 7.7 (2.0) | 118.8*(41.9-336.6) | 10.5* | 14.4* | |
| (n) | (2948) | (1070) | (982) | (620) | (276) | ||||||||
| II. Developing | |||||||||||||
| Any other mood disorder4 | 22.9 (1.2) | 45.4*(36.6-56.5) | 20.5 (1.7) | 32.8*(24.1-44.7) | 20.5 (1.9) | 42.3*(27.3-65.4) | 23.5 (2.2) | 86.1*(42.2-175.8) | 45.2 (3.8) | 198.6*(106.2-371.5) | 18.0* | 33.8* | |
| Any anxiety disorder4 | 38.9 (1.3) | 5.9*(5.2-6.8) | 38.4 (2.3) | 5.9*(4.7-7.5) | 40.5 (2.5) | 5.5*(4.3-6.9) | 41.1 (3.2) | 6.5*(4.7-9.0) | 29.8 (3.9) | 5.7*(3.5-9.4) | 1.2 | 1.0 | |
| Any substance disorder4 | 7.5 (0.8) | 3.5*(2.7-4.5) | 8.6 (1.3) | 3.6*(2.5-5.2) | 8.1 (1.5) | 3.5*(2.2-5.6) | 4.3 (1.2) | 2.3*(1.2-4.5) | 3.3 (1.5) | 3.5*(1.1-10.9) | 23.2* | 1.7 | |
| Any DSM-IV/CIDI disorder4 | 56.3 (1.5) | 8.1*(7.1-9.4) | 56.8 (2.5) | 8.1*(6.5-10.1) | 54.5 (2.3) | 7.0*(5.6-8.7) | 55.6 (3.5) | 8.4*(6.1-11.5) | 62.0 (4.6) | 15.7*(10.1-24.2) | 3.4 | 8.7* | |
| Number of comorbid disorders | |||||||||||||
| One5 | 30.9 (1.3) | 5.7*(4.8-6.7) | 30.2 (2.2) | 5.6*(4.3-7.2) | 27.6 (2.0) | 4.6*(3.7-5.8) | 34.1 (3.0) | 6.3*(4.4-9.1) | 41.5 (3.9) | 11.7*(7.5-18.2) | 3.5 | 12.2* | |
| Two5 | 14.1 (0.9) | 14.1*(11.1-17.7) | 15.4 (1.7) | 14.4*(10.2-20.4) | 12.8 (1.4) | 11.1*(8.0-15.4) | 14.0 (1.7) | 14.9*(9.0-24.5) | 11.7 (2.7) | 33.3*(14.9-74.4) | 1.8 | 3.8 | |
| Three or more5 | 11.3 (0.8) | 28.5*(21.5-37.8) | 11.2 (1.3) | 28.0*(19.5-40.3) | 14.1 (1.8) | 24.2*(14.4-40.7) | 7.6 (1.4) | 27.0*(13.1-55.8) | 8.8 (2.3) | 146.8*(43.5-495.6) | 8.0* | 171.4* | |
| (n) | (2231) | (877) | (716) | (440) | (198) | ||||||||
Significant at the .05 level, two-sided test
The results in this table are based on a series of multivariate logistic regression equations in which a dichotomous predictor for a single 12-month comorbid disorder was used to predict a dichotomous measure of 12-month MDE controlling for respondent sex, education and marital status.
Entries in the % columns represent the conditional prevalence estimate (and standard error of that estimate) of each comorbid disorder among respondents with 12-month MDE. Entries in the OR columns represent the odds-ratio (OR) and 95% Confidence Interval (95% CI) of the OR between MDE and the comorbid disorder estimated in the logistic regression equation.
The χ2 tests in the Age Differences columns test the statistical significance of age differences in conditional prevalence of the comorbid disorders among respondents with MDE (%) and of the ORs between MDE and the comorbid disorders (OR). The tests are 2 degree of freedom tests in the case of the disorders where prevalence in the 65+ sub-sample was zero (agoraphobia, adult separation anxiety disorder, and substance disorders).
Other mood disorders include dysthymia and bipolar disorder; Anxiety disorders include panic disorder, generalized anxiety disorder, agoraphobia without panic, specific phobia, social phobia, posttraumatic stress disorder, and adult separation anxiety disorder; Substance disorders include alcohol abuse, alcohol dependence, substance abuse, and substance dependence; Any disorder includes all mood, anxiety, and substance disorders and intermittent explosive disorder
The ORs associated with number of comorbid disorders are based on a single equation in each age group to predict 12-month MDE from three dichotomies for one, two, and three or more comorbid disorders in comparison to the contrast category of no such disorders. As with the other equations, controls were included for sex, education and marital status