Table II.
ORs of Incident Hypertension According to Quartile of Insulin Sensitivity (MFFM)
| Parameter | Continuous (Per 1‐Unit Decrease) | Quartile 4 Median (Range) 10.6 (9.3–24.5) | Quartile 3 Median (Range) 8.4 (7.6–9.2) | Quartile 2 Median (Range) 6.9 (6.3–7.5) | Quartile 1 Median (Range) 5.5 (2.9–6.2) |
|---|---|---|---|---|---|
| No. of cases | 742 | 162 | 181 | 194 | 205 |
| Age‐matched | 1.08 (1.04–1.14) | 1.0 (reference) | 1.22 (0.92–1.63) | 1.42 (1.06–1.89) | 1.60 (1.19–2.14) |
| Multivariate | |||||
| Model 1 | 1.05 (1.00–1.11) | 1.0 (reference) | 1.14 (0.85–1.53) | 1.24 (0.92–1.67) | 1.32 (0.97–1.81) |
| Model 2 | 1.04 (0.99–1.10) | 1.0 (reference) | 1.13 (0.83–1.54) | 1.22 (0.88–1.68) | 1.25 (0.89–1.75) |
| Model 3 | 1.04 (0.97–1.11) | 1.0 (reference) | 1.01 (0.70–1.47) | 1.23 (0.85–1.78) | 1.11 (0.74–1.66) |
| Model 4 | 1.04 (0.98–1.11) | 1.0 (reference) | 1.02 (0.69–1.49) | 1.21 (0.83–1.78) | 1.09 (0.71–1.65) |
Abbreviations: MFFM, glucose disposal rate (M) corrected for fat‐free mass; ORs, odds ratios. Results are expressed as ORs (95% confidence interval). Model 1, adjusted for body mass index (BMI). Model 2, adjusted for BMI, alcohol, physical activity, smoking status, and family history of hypertension. Model 3, adjusted for BMI, alcohol, physical activity, smoking status, family history of hypertension, and systolic blood pressure (SBP). Model 4, adjusted for BMI, alcohol, physical activity, smoking status, family history of hypertension, SBP, and for the following biomarkers: uric acid, estimated glomerular filtration rate and total cholesterol.