Table IV.
Odds of Incident Hypertension According to MFFM, Stratified by Age
| Parameter | Continuous (Per 1‐Unit Decrease) | Quartile of MFFM (Unit) | |||
|---|---|---|---|---|---|
| Quartile 4 10.6 (9.3–24.5) | Quartile 3 8.4 (7.6–9.2) | Quartile 2 6.9 (6.3–7.5) | Quartile 1 5.5 (2.9–6.2) | ||
| Age <60 y | |||||
| No. of cases | 324 | 72 | 73 | 89 | 90 |
| Age‐matched | 1.15 (1.06–1.24) | 1.0 (reference) | 1.35 (0.87–2.09) | 1.68 (1.08–2.62) | 1.92 (1.21–3.06) |
| Model 1 | 1.12 (1.04–1.22) | 1.0 (reference) | 1.28 (0.82–1.98) | 1.52 (0.97–2.39) | 1.67 (1.03–2.70) |
| Model 2 | 1.14 (1.05–1.24) | 1.0 (reference) | 1.34 (0.82–2.17) | 1.62 (0.98–2.67) | 1.92 (1.12–3.29) |
| Model 3 | 1.15 (1.04–1.28) | 1.0 (reference) | 1.51 (0.82–2.75) | 1.89 (1.04–3.45) | 1.97 (1.05–3.71) |
| Model 4 | 1.15 (1.04–1.28) | 1.0 (reference) | 1.45 (0.78–2.67) | 1.91 (1.01–3.59) | 1.93 (1.01–3.71) |
| Age >60 y | |||||
| No. of cases | 418 | 90 | 108 | 105 | 115 |
| Age‐matched | 1.03 (0.97–1.10) | 1.0 (reference) | 1.07 (0.72–1.59) | 1.20 (0.81–1.78) | 1.35 (0.90–2.02) |
| Model 1 | 0.99 (0.93–1.07) | 1.0 (reference) | 0.97 (0.66–1.48) | 1.04 (0.68–1.57) | 1.09 (0.70–1.69) |
| Model 2 | 0.97 (0.90–1.04) | 1.0 (reference) | 0.91 (0.59–1.39) | 1.00 (0.65–1.53) | 0.89 (0.56–1.41) |
| Model 3 | 0.95 (0.87–1.04) | 1.0 (reference) | 0.67 (0.40–1.14) | 0.91 (0.55–1.50) | 0.68 (0.38–1.20) |
| Model 4 | 0.97 (0.88–1.07) | 1.0 (reference) | 0.67 (0.39–1.16) | 0.96 (0.56–1.64) | 0.67 (0.37–1.24) |
Abbreviation: MFFM, glucose disposal rate (M) corrected for fat‐free mass. Results are expressed as odds ratios (95% confidence interval). Model 1, adjusted for body mass index (BMI). Model 2, adjusted for BMI, alcohol, physical activity, smoking status, and family history of hypertension. Model 3, adjusted for BMI, alcohol, physical activity, smoking status, family history of hypertension, and systolic blood pressure (SBP). Model 4, adjusted for BMI, alcohol, physical activity, smoking status, family history of hypertension, SBP, and for the following biomarkers: uric acid, estimated glomerular filtration rate, and total cholesterol.