Skip to main content
. Author manuscript; available in PMC: 2011 Jul 19.
Published in final edited form as: Psychogeriatrics. 2009 Jun;9(2):103–109. doi: 10.1111/j.1479-8301.2009.00289.x

Figure 4.

Figure 4

Colocalization of I2PP2A with protein phosphatase 2A (PP2A) and with phosphorylated tau in Alzheimer disease (AD) brain.27 (a) Subcellular localizations of I2PP2A and the PP2A catalytic subunit in AD hippocampus. I2PP2A was colocalized with PP2A in the neuronal cytoplasm. (b) I2PP2A was colocalized with phosphorylated tau in mostly early stage (white arrow) to middle stage (white arrowhead), where neurofibrillary changes were seen using a phosphorylation-dependent antibody to abnormally hyperphosphorylated (p-) tau in the AD temporal cortex. Neurons that expressed I2PP2A mainly in the nucleus did not colocalize with p-tau (black arrows). Modified and reproduced with the permission from the American Society for Investigative Pathology from Tanimukai et al.27