Table 1.
Characteristics of patients with MIS
| No. | Age/Sex (mo) | Etiology | Time (hr) | CRH (pg/ml) | ACTH (pg/ml) | Cortisol (ng/ml) | IL-1 (pg/ml) |
|---|---|---|---|---|---|---|---|
| 1 | 3.5/M | Congenital CMV | 4 PM | 30 | — | 1.04 | — |
| 2 | 10/M | Cryptogenic (DD) | 9 PM | 70 | — | 0.96 | 16 |
| 3 | 8/M | Cryptogenic (NL) | 10 AM | 56 | — | 1.24 | — |
| 4 | 5.5/F | Cryptogenic (NL) | 7 PM | 65 | 40 | — | — |
| 5 | 7/F | Meningitis | 11 AM | 37 | 51 | 1.28 | 15 |
| 6 | 6/F | Congenital malformation | 8 AM | 45 | 27 | 1.30 | ND |
| 7 | 6/M | Down’s syndrome | 12 PM | 26 | 18 | 1.76 | ND |
| 8 | 3/M | Cryptogenic (DD) | 4 PM | 55 | 25 | 0.96 | — |
| 9 | 5/F | Neurodegenerative disease | 4 PM | 50 | 21 | 2.00 | — |
| 10 | 6/F | Cryptogenic (DD) | 3 PM | 41 | 38 | 1.72 | — |
| 11 | 12/M | Hydrocephalus | 1 PM | 32 | 21 | 1.36 | — |
| 12 | 4/F | Cryptogenic (NL) | 9 AM | 20 | — | — | ND |
| 13 | 5/F | Congenital hydrocephalus | 6 PM | — | 36 | 1.15 | ND |
| 14 | 11/M | Congenital malformation | 10 PM | — | 37 | 0.50 | — |
DD Developmentally delayed.
NL Normal development.
ND Nondetectable.