Table 1.

Summary of animal studies using CRH antagonists

Study	Species	Age	Dose, μg/kg	Route	Results	Side effects
Rivier et al. [45]	rat	adult	800–2,400	i.v.	block CRH, stress	none
Brown et al. [46]	rat	adult	250	i.v.	block stress	none
Fisher et al. [47]	rat	adult	180–3,000	i.v.	block CRH, stress	none
Corder et al. [48]	rat	adult	1,000	i.v.	block CRH	none
Winslow et al. [49]	monkey	adult	10	i.c.v.	block CRH	none
Lyons et al. [50]	rat	adult	1,000	i.c.v.	block stress	none

Fisher et al. evaluated several doses, the results of which are given in table 2. i.v. = Intravenous; i.c.v. = into the lateral cerebral ventricle.