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Effects of CRH antagonists on autonomic and hormonal parameters in the rodent
| Parameter | Vehicle | Helical CRH (9–41) | Dose, μg/kg |
|---|---|---|---|
| MAP, mm Hg | 103±1 | 104±2 | 180 i.v. |
| HR, beats/min | 384±4 | 382±4 | 180 i.v. |
| Norepinephrine, pg/ml | 309±20 | 248±11 | 360 i.c.v. |
| Epinephrine, pg/ml | 58±30 | 42±7 | 360 i.c.v. |
| ACTH, pg/ml | 40±7 | 37±4 | 3,000 i.v. |
| β-Endorphin, pg/ml | <300 | <300 | 3,000 i.v. |
MAP = Mean arterial pressure; i.v. = intravenous; i.c.v. = into the lateral cerebral ventricle.
