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. Author manuscript; available in PMC: 2011 Jul 19.
Published in final edited form as: JAMA. 2008 Jan 30;299(4):417–424. doi: 10.1001/jama.299.4.417

Table 4.

Magnitude of Secondhand Smoke Effect by Genotype by Linear Regression of Maximum FEV1 Cystic Fibrosis Percentile

Genotype Groupa No. of Individuals Linear Regression Coefficientb P Value
CFTR
  ΔF508 homozygote 399 −0.064 .11
 0 or 1 ΔF508 alleles 405 −0.128 .001
TGFβ1 −509
 CC 369 −0.067 .08
 CT 304 −0.086 .05
 TT 84 −0.227 .006
TGFβ1 codon 10
 CC 106 −0.203 .005
 CT 304 −0.049 .22
 TT 244 −0.064 .16
a

Of the 812 individuals with data on maximum forced expiratory volume in the first second of expiration (FEV1) cystic fibrosis percentile and secondhand smoke exposure at home, only 804, 757, and 654 individuals had CFTR, TGFβ1 −509, and TGFβ1 codon 10 genotypes available, respectively.

b

This column contains single linear regressions with maximum FEV1 cystic fibrosis percentile as the dependent variable and secondhand smoke exposure in the home as the independent variable.