Table 3.
Phase | n | Regimen | RR (%) | PFS (m) | OS (m) | |
---|---|---|---|---|---|---|
Bang et al37 | III | 298/296 | Tr-C-5-FU/C-5FU | 47/35 (P = 0.0017) | 6.7/5.5 (P = 0.0002) | 13.8/11.1 (P = 0.0046) |
Kang et al38 | III | 387/387 | B-C-5-FU/C-5FU | 38/29.5 (P = 0.0121) | 6.7/5.3 (P = 0.0037) | 12.1/10.1 (NS) |
El-Rayes et al39 | II | 38 | B-O-D | 42 | 6.6 | 11.1 |
Sun et al40 | II | 44 | Sor-C-D | 41 | 5.8 | 13.5 |
Abbreviations: n, number of patients; RR, response rate; TTF, time to treatment failure; PFS, progression free survival; OS, overall survival; Tr, trastuzumab; C, cisplatin; 5-FU, 5-fluorouracil; B, bevacizumab; O, oxaliplatin; D, docetaxel, Sor, sorafenib.