Figure 4.
Anti-inflammatory action of lipoxin A4 in endometrium and decidua tissue. Cultured endometrial tissue consisting of four individual tissues taken across the menstrual cycle (one proliferative, two early secretory, and one late secretory samples) stimulated with the inflammatory stimulus PMA showed a significant increase in the expression of the inflammatory cytokines IL6 (A) and IL8 (B). The expression of these markers was significantly reduced when tissue was cultured with PMA in combination with lipoxin A4. PMA also stimulated an increase in the expression of IL6 (C) and IL8 (D) in cultured decidua tissue (n=6 from gestational ages 7–12 weeks), which was significantly attenuated by the presence of lipoxin A4. Data are mean±s.e.m. *, **, and ***Represent significance at P<0.05, P<0.01, and P<0.001, respectively, as determined by t test.