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. 2011 Jul 6;31(27):9910–9922. doi: 10.1523/JNEUROSCI.2114-11.2011

Figure 2.

Figure 2.

Locomotor function is improved and lesion pathology is reduced after SCI in CX3CR1GFP/GFP mice. Overground locomotion (BMS score) was improved in CX3CR1GFP/GFP compared to wild-type mice (A). CX3CR1GFP/GFP mice have more spared myelin at and nearby the site of injury (B) and significantly shorter contusion lesions (C, D). Note the marked attenuation of tissue pathology within 0.4 mm of the injury site in CX3CR1GFP/GFP mice (D). Immunofluorescent double labeling for myelin basic protein (MBP) and neurofilament confirms the increased myelin and axon sparing in CX3CR1GFP/GFP mice (E, F). Inset in E and F is zoomed image of white box shown. Data are average of two independent studies using n = 4–6 mice/genotype. Data were analyzed via repeated-measures two-way ANOVA (A) and unpaired t tests (B, C). *p < 0.05, **p < 0.01, ***p < 0.001 versus wild-type. Scale bars, 100 μm.