Figure 8. Helicase function on DNA.
(A) Structure of Hel308 helicase with partially unwound DNA bound to it (2P6R) in the front and side views. The DNA strands are shown as green; the direction of translocation along the unwound single strand is to
. The coloring of the domains is the same as in the other figures, but the top part of domain 3, referred to as the arch subdomain, is colored in purple here. (B) Schematic drawing of XPD helicase with the single DNA translocation strand positioned according to Ref. [32]. In this protein, the direction of translocation is
to
. (C) Possible orientation of the branched duplex DNA in Hef helicase as proposed in Ref. [30] (schematic drawing). In all panels, arrows indicate possible domain motions.