Skip to main content
. 2011 Jul 19;6(7):e19286. doi: 10.1371/journal.pone.0019286

Figure 2. MCH effects on apomorphine-induced PPI deficits in mice.

Figure 2

A. Effect of apomorphine (0, 0.75, 2.5, 5 mg/kg) on PPI (**p<0.01 vs. VEH, one-way ANOVA, with Dunnett's test; n = 5–21). Values represent average of % PPI elicited by three prepulse intensities ± SEM. B. PPI after MCH pretreatment (0, 0.7, 1 nmole) in apomorphine (0.75 mg/kg)-treated mice (*p<0.05, **p<0.01, ***p<0.001 vs. VEH+APO 0.75, two-way ANOVA with Bonferroni test; n = 8–19). C. PPI after MCH pretreatment (0, 1 nmole) in apomorphine (2.5 mg/kg)-treated mice (n = 8). Values (B–C) represent mean % PPI ± SEM. D. Average of PPI values after MCH and/or TPI 1361-17 pretreatment in apomorphine-treated mice (+++ p<0.001, dose effect, one-way ANOVA; **p<0.01 vs. APO 0.75, one-way ANOVA with Dunnett's test; # p<0.05 vs. APO 0.75+MCH1, t-test; ns p>0.05 vs. APO 0.75+MCH1+TPI 3, t-test; n = 8–19). Values represent average of % PPI elicited by three prepulse intensities ± SEM.