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. 2011 Jul 19;6(7):e22077. doi: 10.1371/journal.pone.0022077

Figure 2. Bioinformatics strategy for discovery of the 85 gene ASRA signature.

Figure 2

ASRA genes (“ASRA-up” and “ASRA-down”) are the respective unions of two intersection sets. The ASRA-up intersection was defined as genes that were up-regulated in the ASYM state with respect to the SYM state AND up-regulated in the ASYM state with respect to the p53SYM state. The ASRA-down intersection was defined as genes that were down-regulated in the ASYM state with respect to the SYM state AND down-regulated in the ASYM state with respect to the p53SYM state (See also self-renewal pattern definitions in Fig. 1).