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. 2011 Jul 19;6(7):e22077. doi: 10.1371/journal.pone.0022077

Figure 4. Self-renewal pattern specification by Between Group Analysis (BGA) using the ASRA gene signature.

Figure 4

A self-renewal pattern classification field was developed based on BGA training with the original 8 gene microarray datasets (train; SYM = SYM and p53SYM). The horizontal dashed line delineates symmetric self-renewal character (upper field) and asymmetric self-renewal character (lower field). The specification ability of the method was tested with independently developed microarray datasets for the ASYM and SYM states (control). Hematopoietic DSC-enriched populations include, LSK, ST-HSC, LT-HSC, and MP (multipotent progenitors); MyP, committed myeloid progenitors. ESC, embryonic stem cells; EB, embryoid bodies; iPS, induced pluripotent stem cells; NSC, neural stem cells. Cancer cell populations include mouse mammary cancer derivatives (left) and mouse glioma derivatives (right): SC, stem cells; normal, normal mammary epithelial cells; tumorsp, tumorsphere; neurosp, neurosphere; SP, side population. Immune cells included, plasma cells; GC, germinal center cells; memory B-cells; and naïve B-cells. GSE, Gene Expression Omnibus dataset deposit number.