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. 2011 Jul 19;6(7):e22427. doi: 10.1371/journal.pone.0022427

Figure 1. Episomal maintenance of wild-type and mutant viral genomes.

Figure 1

Southern blot hybridization of a representative HPV16(114/B)-infected HFK cell lines containing wild-type (WT), and C428S, C175S, C185S, and C175,185S mutant genomes. Uncut (U) and single BamHI cut (B) episomal genomes are shown in addition to 1, 10, and 100 viral genome copies per 5 µg of total genomic DNA.