Figure 8. Morphology of HClO-induced apoA-I aggregates.

Panels illustrate representative images of apoA-I samples studied by transmission Electron Microscopy (A) and Atomic Force Microscopy (B,C) A) Protein was incubated at 0.2 mg/mL for 24 h and 37°C at 100 µM HClO. Black arrow shows representative aggregates. B and C) ApoA-I (0.6 mg/mL) for 24 h and 37°C at 100 µM HClO, and loaded stepwise onto the mica. Small size oligomers covering the surface of the mica (represented by the white circle), plus some short (B) and long (C) thin protofibers (white arrows) could be observed. Scale bars are shown in each panel.