Table 1.
Gene expression analysis of the oligodendrocyte lineage genes in frontal cortex (FrCtx), cerebellum (Crb) and the white matter (WM) in 12 months old mice.
| Gene | OLG Lineage marker | FC ratio FrCtx | p-val | FC ratio Crb | p-val | FC ratio WM | p-val |
|---|---|---|---|---|---|---|---|
| PDGFRA | OPC | 1.46 | 5E-04 | −2.00 | 1E-08 | 1.33 | 0.017 |
| CNP1 | OLG | 3.26 | 1E-05 | 1.37 | ns | 1.47 | 0.007 |
| OLIG2 | OLG | 2.45 | 2E-04 | 1.76 | 6E-04 | 1.44 | 0.011 |
| SOX10 | OLG | 1.46 | 2E-09 | −1.06 | ns | 1.56 | 0.006 |
| QKI-5/6 | OLG | 1.60 | 6E-05 | 1.00 | ns | 1.63 | 6E-06 |
| MAG | mature OLG | 6.01 | 1E-08 | 1.28 | ns | 1.62 | 0.015 |
| PLP | mature OLG | 2.27 | 1E-10 | −2.46 | 2E-07 | 1.87 | 4E-04 |
| CLDN11 | mature OLG | 2.79 | 9E-06 | 1.37 | ns | 2.20 | 1E-05 |
| QKI-7 | mature OLG | −1.60 | 8E-05 | −2.09 | 1E-09 | 1.23 | ns |
*
Gene expression from three brain regions were analyzed by qPCR (N=6/group). FC ratio-fold change ratios represent the ratio of means for each gene normalized to the geometric means of two housekeeping genes between controls and ΔhDISC1 mice. Significantly changed genes (t-test, p≤0.05) are highlighted in bold. ns- non-significant.