Table 4.

Gene expression analysis of the cell cycle genes and OPC marker - PDGFRA during development in hindbrain (E15) and cerebellum of P1 and 12 months old mice.

Gene	Cell cycle phase	FC- E15	p-val	FC- P1	p-val	FC- 12mo	p-val
PDGFRA	OPC marker	1.84	4E-03	−1.58	0.01	−2.08	1E-08
CDKN2C/p18Ink4	CDK inhibitor/G1	−1.22	ns	1	ns	−1.03	ns
CDKN1C/p57Kip2	CDK inhibitor/G1	1	ns	−1.45	0.03	−1.21	ns
CDKN1B/p27Kip1	CDK inhibitor/G1	1.08	ns	−1.15	ns	−1.35	5E-07
CCND2	G1 phase	−1.19	ns	−1.07	ns	1.1	0.02
CDC2A	G1/S/G2 phase	−1.88	0.04	−1.06	ns	−1.2	ns
RAD51	S phase	−2.03	0.05	−1.33	ns	−2.06	1E-08
FOXN3	G1/S checkpoint	−1.07	ns	−1.35	0.01	−1.1	Ns

^*Gene expression from frontal cortex were analyzed by qPCR (N=6/group). FC ratio-fold change ratios represent the ratio of means for each gene normalized to the geometric means of two housekeeping genes between controls and ΔhDISC1 mice. Significantly changed genes (t-test, p≤0.05) are highlighted in bold. ns- Non-significant.