Table 5.
Gene | Cell marker | FC FrCtx ΔhDISC1/E12 | p-val ΔhDISC1/E12 | FC WM ΔhDISC1/E12 | p-val ΔhDISC1/E12 |
---|---|---|---|---|---|
PDGFRA | OPC | 1.5/1.1 | 5E-04/ns | 1.3/−1.1 | 0.02/ns |
CNP | OLG | 3.3/2.2 | 1E-05/3E-08 | 1.5/1.5 | 0.007/0.03 |
OLIG2 | OLG | 2.5/2.6 | 2E-04/1E-07 | 1.4/1.5 | 0.01/0.02 |
MAG | mature OLG | 6.0/3.3 | 1E-08/5E-09 | 1.6/1.7 | 0.01/0.002 |
Gene expression from frontal cortex were analyzed by qPCR (N=6/group). FC ratio-fold change ratios represent the ratio of means for each gene normalized to the geometric means of two housekeeping genes between controls and ΔhDISC1 mice. Significantly changed genes (t-test, p≤0.05) are highlighted in bold. ns- Non-significant.