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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Schizophr Res. 2011 May 24;130(1-3):238–249. doi: 10.1016/j.schres.2011.04.021

Table 5.

Gene expression analysis in frontal cortex and white matter of 12 months old ΔhDISC1 mice and the same age mice with delayed expression of mutant ΔhDISC1 at embryonic day 12 (E12/ΔhDISC1) mice as compared to controls.

Gene Cell marker FC FrCtx ΔhDISC1/E12 p-val ΔhDISC1/E12 FC WM ΔhDISC1/E12 p-val ΔhDISC1/E12
PDGFRA OPC 1.5/1.1 5E-04/ns 1.3/−1.1 0.02/ns
CNP OLG 3.3/2.2 1E-05/3E-08 1.5/1.5 0.007/0.03
OLIG2 OLG 2.5/2.6 2E-04/1E-07 1.4/1.5 0.01/0.02
MAG mature OLG 6.0/3.3 1E-08/5E-09 1.6/1.7 0.01/0.002
*

Gene expression from frontal cortex were analyzed by qPCR (N=6/group). FC ratio-fold change ratios represent the ratio of means for each gene normalized to the geometric means of two housekeeping genes between controls and ΔhDISC1 mice. Significantly changed genes (t-test, p≤0.05) are highlighted in bold. ns- Non-significant.