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. Author manuscript; available in PMC: 2012 Sep 26.
Published in final edited form as: Physiol Behav. 2011 Apr 13;104(4):546–554. doi: 10.1016/j.physbeh.2011.04.007

Figure 2.

Figure 2

Mc3r−/− mice develop insulin resistance when subjected to the restricted feeding protocol. (A, B) Serum glucose (A) and insulin (B) levels in WT and Mc3r−/− mice are similar with ad libitum feeding (left panel). However Mc3r−/− mice exhibit abnormal glucose levels and altered insulinemia when subjected to restricted feeding (right panel). The altered insulin observed in Mc3r−/− mice exhibits a circadian pattern; hypoinsulinemia is observed at ZT0, while hyperinsulinemia is observed at ZT6 and ZT12. (C) Mc3r−/− mice are glucose intolerant compared to Mc4r−/− and WT mice; all groups were subjected to the restricted feeding for 2 weeks. * p<0.05 vs. WT within ZT [Adapted from Sutton et al. FASEB J. copyright 2010 with permission from the Federation of American Societies for Experimental Biology]