Table 2.
Relationship between microvesicular steatosis and histological features of NASH from multiple logistic regression analysis
|
Total N |
% with Microvesicular Steatosis |
Odds Ratio (95% CI) |
p-value |
|
|---|---|---|---|---|
| Steatosis | ||||
| <5% (reference) | 65 | 3.1% | ||
| 5–33% | 401 | 7.0% | 2.2 (0.5–9.5) | |
| 34–66% | 318 | 10.4% | 3.6 (0.8–15.4) | <0.001 |
| >66% | 238 | 16.4% | 6.4 (1.5–27.4) | |
| Lobular inflammation | ||||
| <2 under 20X mag (reference)¶ | 538 | 9.1% | ||
| 2–4 under 20Xmag | 372 | 11.3% | 1.2 (0.8–1.9) | 0.68 |
| >4 under 20Xmag | 112 | 9.8% | 1.2 (0.6–2.5) | |
| Ballooning | ||||
| None (reference) | 340 | 4.4% | ||
| Few | 260 | 11.9% | 3.0 (1.5–5.8) | <0.001 |
| Many | 422 | 13.3% | 3.6 (2.0–6.8) | |
| Fibrosis stage | ||||
| 0: None (reference) | 249 | 4.0% | ||
| 1: Zone 3 or portal/periportal | 274 | 7.3% | 1.6 (0.7–3.6) | |
| 2: Zone 3 and periportal | 180 | 14.4% | 4.3 (2.0–9.3) | <0.0001 |
| 3: Bridging | 204 | 13.7% | 4.4 (2.0–9.6) | |
| 4: Cirrhosis | 107 | 15.9% | 5.7 (2.4–13.6) | |
| Megamitochondria | ||||
| Rare/Absent (reference) | 860 | 6.7% | 5.0 (3.1–7.9) | <0.0001 |
| Many | 162 | 27.2% | ||
| Mallory-Denk bodies | ||||
| Rare/absent (reference) | 723 | 8.6% | ||
| Present | 299 | 13.4% | 1.9 (1.2–2.9) | <0.007 |
| NAFLD Activity Score (NAS, range 0–8) | 4.4±1.7 | 1.4(1.2–1.6) | <0.0001 | |
| Presence of NASH | ||||
| No (reference) | 230 | 1.7% | ||
| Borderline/Suspicious | 206 | 8.7% | 6.9 (2.0–23.9) | <0.0001 |
| Definite | 585 | 13.7% | 12.0 (3.7–38.8) | |
¶
Lobular inflammation grades 0 and 1 combined into <2 under 20X mag as the reference category.