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OSE cells isolated from ovaries of Pten;Kras;Amhr2-cre mice are transformed. A.) Mutant OSE cells proliferate faster than WT cells at 24 and 48h. B.) Mutant but not WT OSE cells grow in soft agar (C) and form ectopic tumors in the peritoneal cavity, subcutaneously and under the kidney capsule in vivo (D).
