. Author manuscript; available in PMC: 2012 May 2.

Published in final edited form as: Am J Med Genet B Neuropsychiatr Genet. 2010 Nov 2;0(1):10.1002/ajmg.b.31136. doi: 10.1002/ajmg.b.31136

Table IV.

Association with Diagnoses of Alcohol Dependence for Additive and Full Recessive Effects Models

		GWAS Sample				Replication Sample
SNP	Gene	Additive OR (95% CI)^a	P-Value	Recessive OR (95% CI)^c	P-Value	Additive OR (95% CI)^a	P-Value	Recessive OR (95% CI)^c	P-Value
rs4907240	ARID5A	0.959 (0.799-1.150)	0.648	–	–	0.965 (0.780-1.194)	0.742	–	–
rs13831	GNAS1	1.022 (0.856-1.221)	0.810	–	–	1.135 (0.923-1.397)	0.231	–	–
rs2294015	ANXA13	0.982 (0.835-1.155)	0.824	–	–	0.952 (0.794-1.141)	0.592	–	–
rs7916403	HTR7	1.237 (1.057-1.447)^b	0.00804	1.310 (1.025-1.674)^b	0.0312	1.127 (0.941-1.350)	0.194	1.368 (1.011-1.849)	0.0420

Odds ratio (OR) for the minor allele (unless noted otherwise) under a standard additive genetic effects model.

OR for G allele of rs7916403.

OR for a full recessive genetic effects model for the G allele of rs7916403 (i.e., two-way test of G/G homozygotes versus G/T heterozygotes and T/T homozygotes).