Table 4.
Summary of Results Showing Association (p < .05) with Quantitative Measures
| Chr. | Gene Locus | SNP | F1 |
F2 |
F3 |
F4: Unaffected |
Risk Allele | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| READ | |||||||||||||||||||
| N | β | SE | P | N | β | SE | P | N | β | SE | P | N | β | SE | P | ||||
| 6 | DCDC2 | rs793862 | 3,117 | –.08 | .03 | .006 | 2,936 | –.09 | .03 | .004 | 2,890 | –.08 | .03 | .010 | 2,740 | –.06 | .03 | .042 | A (minor) |
| 6 | DCDC2 | rs807701 | 3,193 | –.05 | .03 | .033 | 3,003 | –.04 | .03 | .090 | 2,954 | –.03 | .03 | .276 | 2,803 | –.02 | .02 | .376 | G (minor) |
| 6 | DCDC2 | rs807724 | 3,085 | –.07 | .03 | .015 | 2,898 | –.07 | .03 | .018 | 2,850 | –.05 | .03 | .091 | 2,700 | –.02 | .03 | .422 | C (minor) |
| 6 | KIAA0319 | rs6935076 | 3,006 | .07 | .03 | .011 | 2,831 | .08 | .03 | .003 | 2,784 | .07 | .03 | .006 | 2,646 | .05 | .02 | .028 | G (major)a |
| 6 | KIAA0319 | rs9461045 | 3,126 | –.08 | .03 | .024 | 2,947 | –.08 | .03 | .026 | 2,901 | –.08 | .03 | .022 | 2,752 | –.05 | .03 | .162 | T (minor) |
| 6 | KIAA0319b | rs2143340 | 3,042 | –.11 | .04 | .001 | 2,864 | –.12 | .04 | .001 | 2,817 | –.12 | .04 | .001 | 2,677 | –.11 | .03 | .001 | G (minor) |
| 16 | CMIP | rs12927866 | 3,055 | –.07 | .03 | .005 | 2,874 | –.08 | .03 | .004 | 2,829 | –.07 | .03 | .005 | 2,690 | –.07 | .02 | .005 | T (minor)a |
| 16 | CMIP | rs6564903 | 3,157 | –.08 | .02 | .002 | 2,966 | –.08 | .03 | .002 | 2,919 | –.08 | .03 | .002 | 2,768 | –.07 | .02 | .002 | T (minor)a |
| 16 | CMIP | rs16955705 | 3,050 | –.06 | .03 | .029 | 2,869 | –.06 | .03 | .022 | 2,824 | –.06 | .03 | .019 | 2,684 | –.05 | .02 | .027 | C (minor)a |
| SPELL | |||||||||||||||||||
| 6 | DCDC2 | rs793862 | 3,094 | –.09 | .03 | .003 | 2,913 | –.09 | .03 | .003 | 2,871 | –.08 | .03 | .009 | 2,729 | –.06 | .03 | .030 | A (minor) |
| 6 | DCDC2 | rs807724 | 3,065 | –.08 | .03 | .007 | 2,878 | –.08 | .03 | .011 | 2,834 | –.06 | .03 | .050 | 2,691 | –.04 | .03 | .204 | C (minor) |
| 6 | KIAA0319b | rs2143340 | 3,023 | –.10 | .04 | .004 | 2,845 | –.10 | .04 | .005 | 2,802 | –.11 | .04 | .004 | 2,669 | –.10 | .04 | .006 | G (minor) |
| 16 | CMIP | rs12927866 | 3,036 | –.06 | .03 | .014 | 2,855 | –.07 | .03 | .009 | 2,814 | –.07 | .03 | .011 | 2,682 | –.06 | .03 | .014 | T (minor)a |
| 16 | CMIP | rs6564903 | 3,136 | –.07 | .02 | .008 | 2,945 | –.07 | .03 | .003 | 2,901 | –.07 | .03 | .004 | 2,758 | –.07 | .02 | .008 | T (minor)a |
| 16 | CMIP | rs16955705 | 3,030 | –.06 | .03 | .026 | 2,849 | –.06 | .03 | .019 | 2,808 | –.06 | .03 | .017 | 2,675 | –.06 | .03 | .027 | C (minor)a |
Only SNPs showing p values < .05 in any group tested are reported; p values statistically significant (< .0023; Methods in Supplement 1) are in bold; β (beta) values are standardized and relative to the minor allele (as defined in Table S3 in Supplement 1).
SNP, single nucleotide polymorphism.
a
Opposite trend compared with original reports (24,36).
b
Within TTRAP.