Table II. Δrad27, pol3-t and Δmms19 mutations increase the recombination potential of distantly separated, diverged inverted Alu repeats.
Orientation of Alu pairs | Distance (bp) | Homology (%) | Recombination rate (× 107) |
|||
---|---|---|---|---|---|---|
wt | Δrad27 | pol3-t | Δmms19 | |||
Direct | 12 | 100 | 4 (3–5) | 23 (17–38) | 26 (11–37) | 3 (2–5) |
Inverted | 100 | 94 | 6 (5–12) | 110 (83–164) | 145 (90–223) | 104 (87–123) |
Median rates and 95% confidence intervals (in parentheses) were calculated as described in Materials and methods.