Table 2.
Effects of the aqueous extract of FBD on the contents of MDA, NO and GSH, and SOD activity in rat brain subject to MCAO.
Group | Dose (mg/kg) | NO (μmol/g prot) | MDA (μmol/g prot) | GSH (μmol/g prot) | SOD (U/mg prot) |
---|---|---|---|---|---|
Sham | 4.58 ± 0.75 | 3.77 ± 0.83 | 45.33 ± 5.54 | 143.07 ± 26.65 | |
MCAO | 7.94 ± 0.74## | 6.68 ± 0.54## | 27.08 ± 3.92## | 96.57 ± 22.78## | |
EGb761 | 24 | 6.01 ± 0.96** | 4.56 ± 1.72** | 35.03 ± 6.06** | 124.43 ± 15.77** |
FBD | 250 | 6.25 ± 0.80** | 4.64 ± 0.96** | 32.51 ± 5.00* | 131.73 ± 22.40** |
All the data were shown as the mean ± SD, n = 10−12. Significance was evaluated with one-way analysis of variance (ANOVA) following by two-sided Dunnett's t-test. ## P < .01 versus the sham-operated group; *P < .05, **P < .01 versus the vehicle-pretreated MCAO group.