Table 2.

The effect of neocortical Alzheimer pathology on the odds of dementia in different age groups

Group	Age range		Mean age	Peak CERAD	Mean CERAD	Braak score	Composite score
Panel A
Univariate analysis
1	70–82	n = 51	76.4 ± 4.3	2.2 (1.2–4.0)	2.1 (1.2–4.5)	2.0 (1.2–3.4)	2.2 (1.3–3.9)
2	83–87	n = 53	85.2 ± 1.7	3.2 (1.6–6.6)	3.5 (1.6–7.5)	2.6 (1.4–4.7)	3.7 (1.8–7.6)
3	88–93	n = 55	90.6 ± 1.6	2.8 (1.6–4.9)	3.0 (1.6–5.5)	2.8 (1.6–5.2)	3.1 (1.7–5.4)
4	94–101	n = 50	96.0 ± 2.1	2.6 (1.4–5.3)	2.7 (1.2–5.8)	1.7 (1.1–2.9)	2.4 (1.3–4.6)
<90	70–89	n = 113	81.7 ± 5.8	2.7 (1.8–3.9)	3.1 (1.9–4.8)	2.3 (1.6–3.4)	2.9 (1.9–4.4)
≥90	90–101	n = 96	93.8 ± 2.9	2.5 (1.6–3.9)	2.8 (1.6–4.5)	2.1 (1.4–3.2)	2.6 (1.7–3.8)
Panel B
Multivariate analysis
1	70–82	n = 51	76.4 ± 4.3	2.1 (1.1–4.3)	2.3 (1.1–4.9)	2.1 (1.2–3.9)	2.2 (1.2–4.1)
2	83–87	n = 53	85.2 ± 1.7	3.3 (1.6–6.9)	3.5 (1.6–7.9)	2.5 (1.3–4.9)	3.5 (1.7–7.5)
3	88–93	n = 55	90.6 ± 1.6	2.7 (1.5–5.0)	3.0 (1.6–6.1)	2.8 (1.5–5.0)	2.9 (1.7–5.1)
4	94–101	n = 50	96.0 ± 2.1	2.7 (1.6–4.7)	3.1 (1.3–8.0)	1.8 (1.1–3.1)	2.9 (1.4–6.0)
<90	70–89	n = 113	81.7 ± 5.8	2.5 (1.7–3.7)	3.2 (2.0–5.3)	2.3 (1.6–3.5)	2.7 (1.9–4.4)
≥90	90–101	n = 96	93.8 ± 2.9	2.7 (1.6–4.6)	2.9 (1.6–5.2)	2.0 (1.4–3.2)	2.7 (1.7–4.3)

The 209 autopsies in the Baltimore Longitudinal Study of Ageing autopsy cohort were divided into four or two groups based on age. Logistic regression analysis of the effects of a step-wise increase in each of the indicated neocortical Alzheimer’s disease pathologies on the odds of dementia are shown as a function of age group along with the 95% confidence intervals. A univariate analysis is presented in panel A, and a multivariate analysis corrected for sex and the weight of the brain at death is presented in panel B. The composite score is a combined weighting of the Braak and CERAD scores as defined in Materials and methods section.