Table 4.

Differences of brain activity between patients with Parkinson’s disease and normal subjects in performing anti-phase movements

Brain region	Coordinates			t-value	Cluster size
	x	y	z
Normal–Parkinson’s disease
SMA-proper	4	−6	54	8.86	136
Right thalamus	14	−10	2	8.59	106
Right globus pallidus	20	−14	−1	8.48	42
Left thalamus	−14	−12	0	8.16	31
Parkinson’s disease–Normal
Left precentral gyrus	−54	−3	9	9.46	323
Left cerebellum, posterior lobe, tonsil	−8	−45	−40	8.77	55
Left inferior parietal lobule	−51	−30	29	8.55	182
Left post-central gyrus	−36	−44	61	8.33	170
Left superior parietal lobule	−34	−46	50	8.14	114
Left precuneus	−16	−44	46	8.11	212
Right cerebellum, posterior lobe, declive	38	−67	−20	7.91	63
Right precentral gyrus	63	5	18	7.74	90
Right inferior frontal gyrus	46	−3	18	7.67	133
Right cerebellum, posterior lobe, tonsil	14	−56	−36	7.49	79
Left post-central gyrus	−14	−53	65	7.46	59
Left SM1	−28	−22	67	7.40	160
Left premotor cortex	−18	−14	62	7.35	84
Left paracentral lobule	−8	−39	68	7.34	120
Right paracentral lobule	6	−34	68	7.06	62
Right precuneus	2	−36	46	7.04	53

List of the brain regions showing significantly more activity in normal subjects than in patients with Parkinson’s disease (Normal–Parkinson’s disease), or more activity in patients with Parkinson’s disease than in normal subjects (Parkinson’s disease–Normal), in performing anti-phase movements (two sample t-test, P < 0.05, corrected). The coordinates are given as stereotaxic coordinates referring to the atlas of Talairach and Tournoux (1988).