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. 2010 Jul 13;133(8):2475–2488. doi: 10.1093/brain/awq159

Figure 1.

Figure 1

Sustained infusion of sumatriptan (0.6 mg/kg/day, s.c.) for 6 days promoted increased and persistent expression of neuronal NOS (nNOS) in the trigeminal ganglia of rats. Immunofluorescence labelling neuronal NOS in the trigeminal ganglion is shown for sections obtained 6 and 21 days after vehicle or sumatriptan pump was implanted (A). Sumatriptan exposure resulted in a significant (P < 0.05) increase in numbers of neuronal NOS-labelled profiles in the trigeminal ganglia, relative to vehicle-infused animals, at both Day 6 and 21 (B). Additionally, dural afferents were identified by application of Fluorogold to the dura and profiles expressing labelling for neuronal NOS (C) were evaluated in the trigeminal ganglia 6 and 21 days after sumatriptan exposure. The relative proportion of profiles obtained from sumatriptan-treated animals and expressing both the retrograde label and label for neuronal NOS in the trigeminal ganglia showed a significant and persistent (Day 6 and Day 21) increase relative to vehicle-infused animals (D). Asterisk indicates P < 0.05 relative to vehicle.