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. 2010 Jul 13;133(8):2475–2488. doi: 10.1093/brain/awq159

Figure 5.

Figure 5

Stress-induced allodynia is blocked by selective neuronal NOS inhibitor. (A–D) Rats received sumatriptan infusion and were challenged on Days 20 and 21 with a single injection of NXN-323 prior to exposure to the bright light environmental stressor. NXN-323 blocked the expression of periorbital (A: Day 20, C: Day 21) and hind paw (B: Day 20, D: Day 21) tactile allodynia in sumatriptan-exposed rats. Two-factor ANOVA indicated significant (P50.05) differences in periorbital and hind paw withdrawal thresholds between the groups receiving vehicle and that receiving NXN-323 on both days. (E–H) On Days 20 and 21 after pump implantation, rats were exposed to bright light for 1 h, which caused a significant reduction in periorbital or hind paw thresholds in sumatriptan-exposed rats. However, co-infusion of sumatriptan and NXN-323 prevented the expression of periorbital (E: Day 20, G: Day 21) or hind paw (F: Day 20, H: Day 21) allodynia.