Table 1.

Wound healing processes and healing phases of the vehicle, negative control, R. sanctus extracts and Madecassol administered animals^a.

Groups	Wound healing processes									Healing phases
	S	U	RE	FP	CD	MNC	PMN	NV	MC	I	P	R
Vehicle	+/+++	++	−/+	++	++	+	+	+/++	+	+++	++	−
Negative control	−/++	+	−/++	+/++	+/++	−/+	+	+/++	+	+++	++	−/+
Hexane extract	+	−	++	+/++	++	−/+	−	+	+	+	+/++	++
Chloroform extract	+	−	++	+/++	++	+	−	+	+	+	+/++	++
Ethyl acetate extract	+	−	++	++	++	+	−	+	+++	+	+/++	++
Methanol extract	+	−	+++	+	++	−/+	−	−/+	+	−/+	−/+	+++
Madecassol	+/++	−	++	++	++	−	−	++	+/++	+/++	++	+

S: Scab; U: Ulcus; RE: re-epithelization; FP: fibroblast proliferation; CD: collagen depositions; MNC: mononuclear cells; PMN: polymorphonuclear cells; NV: neovascularization; MC: Mast cells; I: inflammation phase; P: proliferation phase; R: re-modeling phase.

^aHE, VG and TB stained sections were scored as mild (+), moderate (++) and severe (+++) for epidermal and/or dermal re-modeling.